HLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer.

ABSTRACT:

Introduction

The concept that human leukocyte antigen-G (HLA-G) expression is specifically in various malignant lesions but absent in adjacent normal tissues has been well documented, and HLA-G is acknowledged as a novel immune checkpoint.

Methods

In this study, HLA-G expression in 523 gastric cancer (GC) lesions and 283 case-matched peritumoral tissues (PTTs) was analyzed by immunohistochemistry. The clinical significance of HLA-G expression in GC lesions and case-matched PTTs was evaluated, and a specific HLA-G-positive subpopulation in PTTs was identified.

Results

Data showed that HLA-G expression was significantly different between GC lesions (370/523, 70.7%) and PTTs (238/283, 84.1%; p<0.001). HLA-G in GC lesions was more frequently observed in older patie

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12571866 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature