Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease.

ABSTRACT: Rapidly progressive glomerulonephritis (RPGN) is the most aggressive group of autoimmune kidney diseases and is characterized by glomerular crescent formation with proliferation of parietal epithelial cells (PECs). However, the underlying mechanisms of glomerular crescent formation are incompletely understood. Here we provide a high-resolution spatial kidney cell atlas of 57 samples from patients with RPGN (ANCA-associated GN, lupus nephritis and anti-glomerular basement membrane-GN) to characterize the cell signaling pathways in glomerular crescent development. Early platelet-derived growth factor (PDGF) signaling from epithelial and mesangial cells caused PEC activation and proliferation in glomerular crescents, whereas later transforming growth factor (TGF)-β signaling from macrophages,

SUBMITTER: Sultana Z 

PROVIDER: S-EPMC12571875 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature