Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis.

ABSTRACT: Neural activity is increasingly recognized as a crucial regulator of cancer growth. In the brain, neuronal activity robustly influences glioma growth through paracrine mechanisms¹ and by electrochemical integration of malignant cells into neural circuitry via neuron-to-glioma synapses^2,3. Outside of the central nervous system, innervation of tumours such as prostate, head and neck, breast, pancreatic, and gastrointestinal cancers by peripheral nerves similarly regulates cancer progression^4-12. However, the extent to which the nervous system regulates small cell lung cancer (SCLC) progression, either in the lung or when growing within the brain, is less well understood. SCLC is a lethal high-grade neuroendocrine tumour that exhibits a strong propensity to me

SUBMITTER: Savchuk S 

PROVIDER: S-EPMC12571889 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature