Selective Hippocampal Subfield Atrophy Mediates Cognitive Decline in Cushing's Disease.

ABSTRACT:

Background

Cushing's disease (CD) provides insight into how prolonged high cortisol exposure affects brain structure. While CD patients show cognitive and emotional symptoms linked to hippocampal function and detailed analysis of hippocampal subfield changes remains limited.

Methods

The study included 91 patients with active CD and 53 matched healthy controls who underwent T1-weighted magnetic resonance imaging and comprehensive neuropsychological assessment. We employed voxel-based morphometry, automated segmentation, and shape analysis to evaluate gray matter volume, subfield volumes, and hippocampal morphology. Clinical correlations of hippocampal subfield volumes were also explored.

Results

Compared to controls, CD patients showed decreased hippocampal gray matter

SUBMITTER: Feng Z 

PROVIDER: S-EPMC12571980 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature