Combining Reversible Electroporation and Bleomycin in Treatment of Arteriovenous Malformations.

ABSTRACT:

Purpose

This study aims to evaluate and compare safety and clinical outcomes of reversible electroporation with either intravenous (BEST) or intraarterial (BEET) Bleomycin application treating extracranial AVMs unsuitable for conventional approaches defined as fine-fistulous AVMs close to vulnerable anatomical structures (such as skin/end-arteries) not amenable for embolization or resection due to inappropriate risk/benefit and/or therapy-refractory or recurrent lesions.

Materials and methods

This is a sub-analysis of the prospective multicenter APOLLON trial (German clinical trial register, DRKS00021019). Clinical and imaging findings were assessed at baseline and 6-month follow-up to evaluate subjective outcome (symptom-free, partial relief, no improvement, clinical progre

SUBMITTER: Obereisenbuchner F 

PROVIDER: S-EPMC12571998 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature