Clinical, toxicity and long-term neurocognitive outcomes of first-line intensive chemotherapy in infant medulloblastoma: a single-center cohort study following AIEOP recommendations.

ABSTRACT:

Purpose

The long-term neurocognitive impact of craniospinal irradiation (CSI) in young children with medulloblastoma (MB) has driven the development of alternative strategies aimed at improving survival while delaying or avoiding CSI.

Methods

We retrospectively analyzed a cohort of patients under 5 years of age with MB treated at Bambino Gesù Children's Hospital between 2007 and 2023 with intensive chemotherapy regimens according to AIEOP recommendation. Clinical, radiological, histopathological, molecular, neurocognitive, and toxicity data were collected.

Results

Among 42 patients under 5 years, 25 met inclusion criteria (median age 25.3 months, range 5.0-51.3). Histology included classic (52%), desmoplastic/nodular (20%), extensive nodularity (16%), and large cell/a

SUBMITTER: Del Baldo G 

PROVIDER: S-EPMC12572033 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature