Fabrication and characterization of an anti-corrosion/infection VAN@PLGA/HA/CMCS composite coating on magnesium alloy.

ABSTRACT: The study aims to develop a composite coating for magnesium aluminum alloy (MA) to improve its corrosion/infection resistance. MA was coated with carboxymethyl chitosan (CMCS) and nano-hydroxyapatite (HA) through electrophoretic deposition, followed by the deposition of vancomycin-loaded polymer nanoparticles to obtain the ternary composite coating alloy (VAN@PLGA/HA/CMCS-MA). In simulated body fluid (SBF), the average corrosion rate of the coating alloy was 0.27 ± 0.03 mg/cm^-1/day^-1, while maintaining a pH level of approximately 7.2, indicating that the composite coatings effectively mitigated erosion in SBF and ensured a stable physiological pH. In vitro antibacterial experiments showed that VAN@PLGA/HA/CMCS-MA exhibited enhanced antibacterial activity against staph

SUBMITTER: He J 

PROVIDER: S-EPMC12572056 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature