A systematic review of core outcomes reported in boys and men with Klinefelter syndrome.

ABSTRACT:

Purpose

Klinefelter syndrome (XXY) has a wide range of presentations and health consequences. The aim of this systematic review was to identify potential core outcomes reported in males with XXY.

Methods

Systematic searches of PubMed, Science Direct, and Cochrane were performed to source studies. The inclusion criteria were studies involving males with KS with any intervention, comparison, or outcome, with separate searches for studies reporting on children <16 years of age and for adults ≥16 years of age.

Results

For children <16 years old, 56 studies met the eligibility criteria. Thirty-seven (66%) studies reported anthropometric measurements and physical characteristics. Behavioural, cognitive developmental and psychiatric outcomes were also commonly reported (27,

SUBMITTER: Frixou M 

PROVIDER: S-EPMC12572081 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature