Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment.

ABSTRACT: This study aimed to characterize meropenem pharmacokinetics and optimise dosing for the initial and steady state in critically ill patients. Adult patients receiving meropenem were recruited, with sampling performed on days 1 (Occasion 1) and 3 (Occasion 2) of therapy. A composite target of free drug concentrations above the minimum inhibitory concentration for the entire dosing interval (100%ƒT > MIC) and a concentration below the toxicity threshold of 45 mg/L was used. Thirty-seven patients, with a median age of 52 years, and a median estimated creatinine clearance (CLcr) and CKD Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) of 68.6 mL/min and 78.2 mL/min/1.73 m², respectively, were recruited. Twenty-four patients reached the composite target

SUBMITTER: Sulaiman H 

PROVIDER: S-EPMC12572147 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature