Excess short- and long-term mortality risk following any and hip fractures: a prospective matched cohort study using exposure density sampling.

ABSTRACT: Evidence on the magnitude and duration of short- and long-term mortality following osteoporotic fractures was mixed. We aimed to examine the short- and long-term mortality risk after any and hip fractures. We conducted an "exposure density sampling" dynamically matched cohort study based on 363,884 adults from the UK Biobank, with a 1:4 (case: control) matching on age, sex, and frailty status. A piecewise Cox proportional hazards model was used to estimate mortality risk in different time periods from 30 days to 10 years after fractures. For any fracture, the nested analysis cohort included 19,163 cases and 67,522 matched controls, with a mean (SD) age of 58.3 (7.8) years and 59.5% of the cohort being women. During follow-up, men had a higher post-fracture mortality rate than women (15.85

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12572153 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature