Mechanistic analysis of luteolin in mitigating dry age-related macular degeneration through network pharmacology and experimental validation.

ABSTRACT: Dry age-related macular degeneration (AMD) ranks among the primary causes of irreversible vision loss in the elderly. Luteolin, with its diverse biological activities, has attracted significant attention as a promising candidate for intervening in dry AMD. Explore the protective effect of luteolin on dry AMD to address the unmet need for current therapeutic agents. Luteolin's target information and dry AMD-related genes were retrieved from public databases. Shared targets of luteolin and dry AMD were used to construct a protein‒protein interaction network, followed by Gene Ontology and pathway enrichment analyses. Finally, molecular docking between the active ingredient and core targets was validated. In vitro, sodium iodate was used to induce ARPE-19 cells, after which cell viability was

SUBMITTER: Luo M 

PROVIDER: S-EPMC12572168 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature