Catalytic asymmetric synthesis of (N, N)- spiroketal via Pd-catalyzed enantioconvergent aminocarbonylation and dearomative nucleophilic aza-addition.

ABSTRACT: Chiral spirocyclic skeletons have found widespread applications in asymmetric catalysis, drug discovery, and functional materials due to their rigid three-dimensional architecture and excellent stereochemical stability. However, the structural diversity of accessible spiro frameworks remains limited, constraining their broader utility and functional development. For instance, chiral (N, N)-spiroketals represent a promising class of scaffolds with potential application in asymmetric catalysis and are frequently encountered in natural products and biologically active compounds, yet their efficient synthesis is still underdeveloped. Herein, we present a Pd-catalyzed cascade enantioconvergent aminocarbonylation and intramolecular dearomative nucleophilic aza-addition that enables the efficient

SUBMITTER: Su L 

PROVIDER: S-EPMC12572194 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature