Pathogenic genes associated with immune-related genes in graves' disease: a multi-omics Mendelian randomization analysis.

ABSTRACT: Immune-related genes (IRGs) have been implicated in autoimmune diseases, but their causal role in GD remains unclear. We conducted a multi-omics Mendelian randomization (MR) analysis integrating genome-wide association study (GWAS) data from GD patients with blood-based methylation quantitative trait loci(mQTLs), expression QTLs(eQTLs), and protein QTLs(pQTLs). SMR analysis was performed to assess the causal associations between IRGs and GD, followed by HEIDI tests to screen for pleiotropy. Colocalization analysis identified shared genetic determinants. We further validated the findings in Finngen R10 and GWAS catalog dataset and explored the regulatory associations between mQTLs, eQTLs, and pQTLs. Through SMR analysis (P-SMR-multi < 0.05, P-SMR < 0.05, P-HEIDI > 0.01), we identified 301 m

SUBMITTER: Ji Q 

PROVIDER: S-EPMC12572219 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature