Exploring compositional and predicted functional alterations of gut microbiota in H. pylori infection.

ABSTRACT: H. pylori infection is prevalent worldwide having detrimental effects on the gastrointestinal tract. H. pylori has been linked to compositional variations in gastric microbiota, with insufficient knowledge on extended effect to intestinal microbiota. Moreover, functional potentials of gut microbiota remain underexplored. Aim We sought to investigate the compositional and functional shifts in gut microbiota associated with H. pylori infection. Total 54 stool samples were obtained from H. pylori infected patients tested positive for stool antigen (n = 31) compared to control group (n = 23). All samples were subjected to 16SrRNA next-generation sequencing. By comparison with the control group, the H. pylori-positive group displayed relatively higher mean relative abundance (RA) of phyla of Ba

SUBMITTER: Soliman NS 

PROVIDER: S-EPMC12572280 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature