Concomitant use of antidepressants and classic psychedelics: A scoping review.

ABSTRACT: Classic psychedelics are increasingly studied as potential treatments for different psychiatric disorders. Current research protocols often require patients to discontinue antidepressants (ADs) for at least 2 weeks before psychedelic administration to decrease the risk of serotonin syndrome and limit their effect on efficacy and the acute subjective effects of psychedelics. Moreover, the discontinuation of ADs represents a significant burden to patients that could also worsen their depression status and increase suicidal ideation. Together, this suggests that the general recommendation for AD discontinuation might be unnecessary and even detrimental to the therapeutic efficacy of psychedelics. In this scoping review, we summarise the existing literature on the concomitant use of convention

SUBMITTER: Tap SC 

PROVIDER: S-EPMC12572353 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature