Cardio-renal protection and mechanisms of the antihypertensive activity of Alcalase-derived moth bean hydrolysate in DOCA-salt induced hypertensive Wistar rats.

ABSTRACT: Hypertension remains a major global health concern, often leading to severe cardiovascular and renal complications. In this study, we investigated the antihypertensive and cardiorenal protective effects of AF4, a bioactive Alcalase derived peptide fraction (< 1 kDa) derived from moth bean protein hydrolysate, in a DOCA-salt hypertensive rat model. AF4 administration significantly reduced systolic blood pressure in a dose-dependent manner, with the minimum effective dose (75 mg/kg body weight/day) selected for further mechanistic evaluation. Treatment with AF4 improved various physiological parameters, including heart rate, cardio-myocytes conduction, electrocardiogram (ECG) abnormalities, and kidney function markers. Biochemical analyses revealed that AF4 act as ACE inhibitor, led to reduc

SUBMITTER: Goyal N 

PROVIDER: S-EPMC12572375 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature