Prospective study of circulating metabolomic profiles and breast cancer incidence among predominantly premenopausal women.

ABSTRACT:

Background

Associations between premenopausal plasma metabolites and breast cancer incidence are largely unknown.

Methods

We conducted a prospective, matched case-control study in which we measured pre-diagnostic metabolomic profiles among predominantly premenopausal women in the Nurses' Health Study II (n = 2010). Lipids, carbohydrates, and organic acid-related metabolites (n = 218) were profiled via liquid chromatography-tandem mass spectrometry. Conditional logistic regression was used to estimate odds ratios (OR) for associations between individual metabolites and breast cancer incidence. Associations with metabolite groups were assessed using metabolite set enrichment analysis (MSEA).

Results

Six individual lipid-related metabolites were nominally associated with

SUBMITTER: Wang T 

PROVIDER: S-EPMC12572396 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature