Lung injury promoted by strong inspiratory efforts and breath stacking: impact of ventilation mode.

ABSTRACT:

Background

Breath stacking, particularly double triggering, is a common patient-ventilator asynchrony during strong inspiratory effort. It can cause excessive tidal volumes and high transpulmonary pressures, contributing to ventilator-induced lung injury (VILI). The mode-specific consequences of breath stacking induced by strong inspiratory effort remain unclear.

Methods

In a porcine model of minimal lung injury, 17 animals were randomized to volume-controlled ventilation (VCV, n = 9) or pressure-controlled ventilation (PCV, n = 8). High respiratory drive was induced with continuous CO₂ inhalation, and ventilator settings were dynamically adjusted to maintain a breath stacking ratio of 40-70% of spontaneous efforts. Measurements included airway and transpulmonary pressures,

SUBMITTER: Norisue Y 

PROVIDER: S-EPMC12572466 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature