CENP-F promotes HCC cell proliferation mediated by super enhancer reader BRD4.

ABSTRACT: Centromere protein F (CENP-F) is highly expressed in hepatocellular carcinoma (HCC), but the specific mechanism by which it regulates the occurrence and development of HCC is currently unclear. The activities of the super enhancer (SE) readers bromodomain-containing protein 4 (BRD4), cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 2 (CDK2) and cyclin-dependent kinase 7 (CDK7) are significantly increased in HCC. This study explored the mechanism of CENP-F regulation in HCC through bioinformatics and cell and animal experiments. We found that the protein levels of CENP-F, CDK1, CDK2, CDK7 and BRD4 were significantly increased in HCC and that CENP-F was closely associated with CDK1, CDK2, CDK7 and BRD4. Downregulation of CENP-F led to a decrease in the protein levels of CENP-F, CDK1

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12572522 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature