Extracellular Vesicle-Derived miRNAs as Diagnostic Biomarkers for Pancreatic Ductal Adenocarcinoma: A Systematic Review of Methodological Rigour and Clinical Applicability.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with currently limited early detection options. Extracellular vesicle (EV)-derived microRNAs (miRNAs) have gained interest as non-invasive diagnostic biomarkers due to their stability in circulation and tumour-specific profiles. However, the methodological robustness of existing literature remains unclear.

Objectives

To systematically evaluate the diagnostic accuracy and methodological quality of studies investigating EV-derived miRNAs for PDAC detection, with a particular focus on adherence to established EV characterisation guidelines.

Design

Systematic review registered with PROSPERO (CRD42024501503) and conducted in accordance with PRISMA 2020 reporting standards.

Methods

We se

SUBMITTER: Patel RD 

PROVIDER: S-EPMC12572613 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature