Interpretable prediction of zinc ion location in proteins with ZincSight.

ABSTRACT: Metal ions are essential for a broad range of biochemical processes in living organisms, with zinc being the second most abundant transition metal ion. Zinc has catalytic, structural, and regulatory functions in proteins, impacting virtually all aspects of cell biology. Currently, there are notable challenges in performing a large-scale accurate systematic analysis of the as-yet unexplored occurrences of zinc ion in nature. To address this, we developed ZincSight for predicting zinc-binding sites. ZincSight performs on par with existing structure-based tools in terms of the precision-recall curve for zinc ion detection, and the accuracy of spatial positioning of the ion, yet it is significantly faster, and offers a straightforward reasoning for its predictions, which is missing even in the

SUBMITTER: Mechtinger G 

PROVIDER: S-EPMC12572635 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature