Microenvironment-responsive hydrogels for spatiotemporal delivery of epigallocatechin gallate and BMP-2 to promote osteoporotic bone defect repair.

ABSTRACT: Regenerating osteoporotic bone defects is still a major challenge. Conventional bone tissue engineering materials often fail to achieve on-demand drug delivery. At the same time, the therapeutic logic of osteoporotic bone defects requires spatiotemporal drug delivery to eliminate excess inflammation and high reactive oxygen species (ROS) at an early stage. When inflammation subsides, appropriate drugs are needed to match osteoblast differentiation and bone regeneration. Therefore, we designed a ROS-responsive Polyvinyl alcohol-4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylphenylboronic acid (PVA-TSPBA) hydrogel loaded with epigallocatechin gallate (EGCG) and bone morphogenetic protein-2 (BMP-2). On the one hand, the ROS-responsive properties of composite hydrogels enable controlled delivery

SUBMITTER: Xiao P 

PROVIDER: S-EPMC12572655 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature