Safety of TNF-α inhibitors therapy in patients with rheumatoid arthritis: an umbrella review.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that is characterized by progressive synovial inflammation and leads to joint destruction, functional decline, and reduced life expectancy. Although tumor necrosis factor-alpha inhibitors (TNFi) have revolutionized RA management by preventing structural damage, their safety profiles remain controversial. Current safety assessments remain fragmented across isolated meta-analyses, failing to address competing risks or incorporate recent pharmacovigilance data. This study compared the adverse effects of anti-TNF therapy in RA and provided a stratified safety profile for optimal treatment selection.

Methods

The research team searched four databases, namely PubMed, Web of Science, EMBASE, and the Cochr

SUBMITTER: Xiao R 

PROVIDER: S-EPMC12572804 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature