Subclinical vascular burden in relation to cognitive decline and impairment: The Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Introduction

Subclinical cardiovascular disorders may be differentially associated with cognitive function, decline, and impairment and point to pathways linking vascular disorders to dementia.

Methods

The Multi-Ethnic Study of Atherosclerosis (MESA) collected detailed subclinical vascular measures at baseline in 6814 participants with follow-up clinical examinations over 20 years. Baseline subclinical vascular measures aggregated into four uncorrelated factor composites: atherosclerosis, arteriosclerosis, blood pressure, and cardiac function. Cognitive performance was measured 10 years after baseline, repeated twice over the subsequent decade, along with detailed cognitive testing and adjudication.

Results

Higher baseline arteriosclerosis and atherosclerosis scores p

SUBMITTER: Tanley J 

PROVIDER: S-EPMC12572826 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature