Severe invasive <i>Streptococcus pyogenes</i> infections: A 15-year observational study with molecular characterization of isolates among intensive care adults.

ABSTRACT:

Background

Improving outcomes among patients with invasive group A Streptococcus pyogenes (iGAS) infections is an unmet clinical need. The main objective of this study was to analyze epidemiological and outcome differences in adults admitted to the intensive care unit (ICU) with iGAS infection over a 15-year period and to evaluate the impact of M1uk isolates and clindamycin optimization on patient outcomes.

Methods

This was a single-center observational study conducted at the ICU of Donostia University Hospital, located in Donostia, Spain. The recruitment of all consecutive adult patients admitted to the ICU by iGAS was carried out from January 2010 to May 2024 and divided into three periods: pre-pandemic (January 2010-2019), pandemic (2020-2021), and post-pandemic (M

SUBMITTER: Vidaur L 

PROVIDER: S-EPMC12572858 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature