Effect of Contemporary Optimal Medical Therapy on Patients With Reduced Ejection Fraction Who Have Undergone Surgery for Severe Chronic Aortic Regurgitation.

ABSTRACT:

Background

Aortic valve replacement (AVR) for chronic aortic regurgitation (AR) in the presence of reduced left ventricular ejection fraction (LVEF) is associated with greater surgical risk. Long-term outcomes remain poorly described in contemporary cohorts.

Methods

Between 2004 and 2019, 122 patients underwent AVR for chronic severe AR with LVEF < 50%. Patients with severely reduced LVEF (< 35%; n = 37) were compared with those with mild to moderately reduced LVEF (35%-50%; n = 85).

Results

Preoperative and intraoperative characteristics were similar in both groups. Operative mortality for the entire cohort was 1.6% (n = 2) and similar across the LVEF spectrum. Postoperatively, optimal medical therapy was achieved in most patients and > 25% of patients with LVEF < 35

SUBMITTER: Blais MC 

PROVIDER: S-EPMC12572892 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature