Clinically important deterioration in a mild-moderate COPD population.

ABSTRACT:

Introduction

Clinically important deterioration (CID), a composite of exacerbation, declines in lung function and health status has been studied as an indicator of disease worsening in moderate-severe COPD clinical populations. We assessed whether CID is predictive of worsening over 18 months in a population-based mild-moderate COPD cohort.

Methods

Canadian Cohort Obstructive Lung disease (CanCOLD) participants with COPD were assessed over 18 months for CID, and over the next 18 months for outcomes. Their association was then examined: 1) defined into threshold-based binary variables, the declines in forced expiratory volume in 1 s (FEV₁), health status and dyspnoea, using logistic regression models; 2) time to moderate/severe exacerbation and rates of moderate/se

SUBMITTER: Biswas S 

PROVIDER: S-EPMC12572958 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature