MiR29a-Loaded Extracellular Vesicles Derived from Human Mesenchymal Stem Cells Inhibit Fibrotic and Inflammatory Signaling.

ABSTRACT: Fibrotic processes involve aberrant deposition of extracellular matrix and contribute to ∼ 45% of all deaths in the developed world. Fibrotic remodeling results in stiffening of the local tissue environment, driving a self-amplifying feedback loop of disease progression that involves hyperactivation of both the YAP/TAZ mechanosensing pathway and the NFκB inflammatory pathway. An important component of this fibrotic remodeling is integrin-dependent compaction of the extracellular matrix. Recent work has identified a network of miRNAs that target cytoskeletal, adhesion, and extracellular matrix-related genes in response to high stiffness, which are important in extracellular matrix mechanical homeostasis. Several of these miRNAs also target fibrosis-related genes, indicating some potential t

SUBMITTER: McDaniel G 

PROVIDER: S-EPMC12572971 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature