Development of a Multifunctional Hydrogel Coloaded with Chitosan-Curcumin and Silver Nanoparticles: Fabrication, Characterization, and Antibacterial Activity.

ABSTRACT: Chronic wounds pose significant clinical challenges due to microbial infections, excessive inflammation, and delayed wound healing. For this purpose, we developed a multifunctional self-healing conductive hydrogel loaded with gelatin (type A) capped silver nanoparticles (AgNPs) and curcumin-embedded bovine serum albumin nanoparticles (CCANPs) to enhance antibacterial activity to enhance wound healing. AgNPs were synthesized via green synthesis using Syzygium samarangense leaf extract, demonstrating potent antibacterial properties. Curcumin, encapsulated in hydroxypropyl-β-cyclodextrin (HPβCD) and chitosan-coated BSA nanoparticles (355.8 ± 9.45 nm size, 87.83% entrapment efficiency), exhibited pH-dependent sustained release (81.65% at pH 1.2, 70.84% at pH 7.4 over 24 h). These nanopa

SUBMITTER: Nabilah R 

PROVIDER: S-EPMC12573014 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature