Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19.

ABSTRACT:

Importance

Given the increased vulnerability to COVID-19 among those with a serious mental illness (SMI), it remains unclear whether these individuals face a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC). Understanding this association could inform secondary prevention efforts.

Objective

To identify the risk of developing PASC in patients with an SMI.

Design, setting, and participants

This longitudinal cohort study used data derived from large-scale electronic health records (EHRs) between March 2020 and April 2023, inclusive of 180-day follow-up. Patients included adults aged 21 years or older with a confirmed COVID-19 infection evidenced by a relevant laboratory result, diagnosis, or prescription order.

Exposures

Evidence of an SMI diagnos

SUBMITTER: Vekaria V 

PROVIDER: S-EPMC12573031 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature