Fe₃O₄-Chitosan Nanocomposite as a pH-Responsive Delivery System for Enhanced Delivery of <i>Punica Granatum</i> L. Polyphenols.

ABSTRACT: Punica granatum extract (PG), consisting of punicalagin, ellagic acid, and gallic acid, was loaded onto an Fe₃O₄/Chitosan (Fe₃O₄@Chi) nanocomposite (Fe₃O₄@Chi-PG) to enhance pharmacokinetic properties. Fe₃O₄ was synthesized via the coprecipitation method and coupled with chitosan in 2% acetic acid solution via glutaraldehyde cross-linking. The presence of interested polyphenols in the pomegranate extract was confirmed by HPLC analysis, and the extract was post-loaded to the nanocarrier. XRD confirmed the crystallographic orientation of the nanocarrier, and SEM analysis confirmed the successful coupling of Fe₃O₄ onto the chitosan surface during the fabrication of Fe₃

SUBMITTER: Rukshan R 

PROVIDER: S-EPMC12573052 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature