<i>Mitracarpus frigidus</i> in the Treatment of Vulvovaginal Candidiasis: A Comprehensive Evaluation of Its Therapeutic Properties.

ABSTRACT: Mitracarpus frigidus (Rubiaceae) is a Brazilian native species traditionally used in folk medicine and has been associated with a range of biological activities, including anti-inflammatory, antibacterial, and antifungal effects. Among the relevant targets, Candida spp. stand out as opportunistic fungi responsible for infections such as vulvovaginal candidiasis, a widespread public health concern aggravated by the growing limitations and reduced efficacy of conventional antifungal therapies. Thus, this study investigated the cytotoxic and in vitro and in vivo antifungal activities of M. frigidus hexanic extract (MFH) against Candida species and its possible mechanism of action. Eleven compounds were identified in MFH, including pentalongin and stigmasterol. I

SUBMITTER: Souza TF 

PROVIDER: S-EPMC12573053 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature