Circ_0000756 Mediates Oxidative Stress and Metabolic Memory in Diabetic Neuropathy via miR-7b Suppression of NRF2/ARE Pathway.

ABSTRACT: Diabetic peripheral neuropathy (DPN) is a common and debilitating complication of diabetes, in which oxidative stress and metabolic memory drive progressive nerve damage. Circular RNAs (circRNAs) have emerged as important regulators in diabetic complications, but their roles in DPN remain poorly understood. RNA sequencing (RNA-Seq) and Weighted Gene Co-Expression Network Analysis (WGCNA) were performed to identify DPN-associated circRNAs in rat sciatic nerves. Multi-omics approaches, including proteomics and metabolomics, were applied to characterize the downstream pathways of circ_0000756. Functional studies in Schwann cells assessed oxidative stress, apoptosis, and inflammatory responses, while a DPN rat model was used to validate in vivo effects. Circ_0000756 was significantly upregulat

SUBMITTER: Chen J 

PROVIDER: S-EPMC12573067 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature