HLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US.

ABSTRACT:

Importance

Carriage of HLA-B*58:01 has been shown to be associated with allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) in many populations globally; however, there is a critical need to investigate whether this is generalizable to populations of mixed ancestry, such as those in the US.

Objective

To assess the association of human leukocyte antigen (HLA) class I and II in a cohort of US patients who received a diagnosis of allopurinol-induced SJS/TEN or DRESS compared with allopurinol-tolerant and population control participants.

Design, setting, and participants

This genetic association study included consenting individuals who had specialist-adjudicated allopurino

SUBMITTER: Campbell CN 

PROVIDER: S-EPMC12573116 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature