Synthesis, Characterization, and Dual Functional Properties of Coumarin-Based Hybrids for Biological and Optical Applications.

ABSTRACT: Heterocyclic compounds incorporating nuclei of coumarin, benzimidazole, and benzothiazole exhibit significant biological and pharmacological properties. This study presents an efficient synthetic route for hybrid molecules integrating coumarin with either benzimidazole or benzothiazole under mild reaction conditions. The antibacterial and antioxidant properties of the synthesized compounds were systematically evaluated. The methodology successfully yielded 11 compounds in total, including six substituted coumarin-benzimidazole and five coumarin-benzothiazole derivatives, with yields ranging from 14 to 60%. Notably, derivatives 19 and 26 exhibited moderate antibacterial activity against Staphylococcus aureus at concentrations of 500 and 250 μg·mL^-1, respectiv

SUBMITTER: Lima JGM 

PROVIDER: S-EPMC12573153 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature