Distinctive Prototyping of Paper-Based Microfluidic Devices via Capillary-Driven Wax Patterning.

ABSTRACT: In this study, we introduce a novel hybrid technique for fabricating two-dimensional paper-based microfluidic analytical devices (μPADs) that combines capillary-driven wax patterning with embossing. The method utilizes capillary action to guide molten wax through a sealed polydimethylsiloxane microfluidic chip onto a glass substrate, where it forms high-resolution wax stamps upon demolding. The wax-glass assembly is then heated to facilitate wax penetration through the paper matrix, creating well-defined hydrophobic-hydrophilic barriers. This process allows precise control over stamp dimensions, offering considerable design flexibility. We systematically examined the relationship between flow time and channel length, with experimental results showing strong consistency with a modified Luca

SUBMITTER: Su Y 

PROVIDER: S-EPMC12573175 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature