Association between buprenorphine dose and outcomes among pregnant persons with opioid use disorder.

ABSTRACT:

Background

Opioid use disorder contributes to maternal morbidity and mortality in the United States. Little is known about how the patterns of buprenorphine dose and duration throughout pregnancy may affect neonatal and postpartum outcomes.

Objective

To determine the associations between trajectories of buprenorphine utilization and dose during pregnancy on maternal and neonatal health outcomes.

Study design

Retrospective cohort study among 2925 pregnant persons with opioid use disorder, followed from the estimated start date of pregnancy through 90 days after delivery. We used administrative healthcare data from Medicaid-enrolled individuals to assess buprenorphine dose and use and maternal (postpartum buprenorphine continuation and overdose) and neonatal (low birthw

SUBMITTER: Jarlenski M 

PROVIDER: S-EPMC12573191 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature