Systems Biological Analysis of Immune-Metabolic Host Responses to Distinct Malaria Parasites.

ABSTRACT: Recent studies suggest differential activation of immune cells and biochemical pathways during infection with distinct etiological agents of human malaria, Plasmodium falciparum or Plasmodium vivax. Rhesus monkeys infected with Plasmodium coatneyi develop pathology comparable to P. falciparum infection in humans, whereas P. vivax is modeled by infection with Plasmodium cynomolgi. To investigate host immune and metabolic responses, we analyzed and integrated public blood flow cytometry, transcriptomics, and untargeted metabolomics data from simian infection models and human malaria. We found conserved dynamics of blood dendritic cells, effector memory CD8+ T cells, and PD-1+ effector memory CD8+ T cells in simian infections; increased expression of

SUBMITTER: Lima DV 

PROVIDER: S-EPMC12573300 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature