Efficacy of open-label placebos for premenstrual syndrome: a randomised controlled trial.

ABSTRACT:

Objective

To investigate the efficacy and safety of open-label placebos (OLP) in premenstrual syndrome (PMS).

Design

Randomised controlled trial.

Setting

Switzerland, 2018-2020.

Participants

150 women (18-45 years of age) with PMS or premenstrual dysphoric disorder.

Intervention

Random assignment (1:1:1) to treatment as usual (TAU), OLP without treatment rationale (OLP-), or OLP with treatment rationale (OLP+). OLP consisted of two placebo pills per day for 6 weeks.

Main outcome measures

Primary outcomes were PMS symptom intensity and interference between groups across three menstrual cycles (MC1-MC3); adverse events (ie, safety) were measured at weeks 3 and 6 after the start of the intervention. Secondary outcomes were psychological and somatic s

SUBMITTER: Frey Nascimento A 

PROVIDER: S-EPMC12573394 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature