Multiple sclerosis from onset to secondary progression: a 30-year Italian register study.

ABSTRACT:

Background

Three decades have passed since the initial approval of disease-modifying therapies (DMTs). Ongoing discussion is focused on fundamental aspects of the disease, highlighting a growing division between successes in managing relapsing multiple sclerosis (MS) and the persistent challenges posed by disease progression.

Methods

A cohort study on prospectively acquired data from the Italian MS register. The primary outcome was to describe the MS disease course from onset to secondary progression (SP) defined according to a data-driven algorithm over 30 years follow-up and according to five different eras of disease onset.

Results

A total cohort of 9958 patients was analysed; 1364 converted to SP after a mean of 8.5 (SD 5.5) years. A higher rate of patients conver

SUBMITTER: Zanghi A 

PROVIDER: S-EPMC12573403 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature