Off-label in-silico flow diverter performance assessment in posterior communicating artery aneurysms.

ABSTRACT:

Background

The posterior communicating artery (PComA) is among the most common intracranial aneurysm locations, but flow diverter (FD) treatment with the widely used pipeline embolization device (PED) remains an off-label treatment that is not well understood. PComA aneurysm flow diversion is complicated by the presence of fetal posterior circulation (FPC), which has an estimated prevalence of 4-29% and is more common in people of black (11.5%) than white (4.9%) race. We present the FD-PComA in-silico trial (IST) into FD treatment performance in PComA aneurysms. ISTs use computational modeling and simulation in cohorts of virtual patients to evaluate medical device performance.

Methods

We modeled FD treatment in 118 virtual patients with 59 distinct PComA aneurysm anatomies,

SUBMITTER: MacRaild M 

PROVIDER: S-EPMC12573414 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature