Efficacy comparison of atropine, orthokeratology and repeated low-level red-light therapy for myopia control in children: a systematic review and network meta-analysis.

ABSTRACT:

Objectives

This study aimed to compare the efficacy of different interventions for myopia control in children, including 0.01% atropine (AP), orthokeratology (Ortho-k), and repeated low-level red-light therapy (RLRL), and their combinations by conducting a network meta-analysis.

Methods

We searched for randomised controlled trials (RCTs) in PubMed, Web of Science and Embase. The primary outcomes were the mean changes in the cycloplegic spherical equivalent (SE) and axial length (AL) at the 12-month follow-up. A Bayesian random-effects network meta-analysis was performed to estimate pooled weighted mean differences and 95% credible intervals.

Results

The analysis included 41 RCTs with 6434 eyes. Compared with the control group, all interventions were found to be effect

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC12573435 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature