Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release.

ABSTRACT: During development, inflammation or tissue injury, macrophages may successively engulf and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis¹. How macrophages may rapidly adapt their transcription to achieve continuous corpse uptake is incompletely understood. Transcriptional pause/release is an evolutionarily conserved mechanism, in which RNA polymerase (Pol) II initiates transcription for 20-60 nucleotides, is paused for minutes to hours and is then released to make full-length mRNA². Here we show that macrophages, within minutes of corpse encounter, use transcriptional pause/release to unleash a rapid transcriptional response. For human and mouse macrophages, the Pol II pause/release was required for continuous efferocytosis in vitr

SUBMITTER: Tufan T 

PROVIDER: S-EPMC12573440 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature