Factors Associated with Risk of Clonal Haematopoiesis of Indeterminate Potential: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Clonal haematopoiesis of indeterminate potential (CHIP) is a risk factor for blood cancers and non-haematological diseases. Understanding factors that lead to CHIP is essential in developing preventive strategies. We aimed to identify factors associated with risk of CHIP through a systemic literature review.

Methods

We searched MEDLINE and EMBASE for original studies reporting an age-adjusted risk measure for factors associated with an outcome of incident or prevalent CHIP. Random effects meta-analyses were performed for factors reported in at least three cohorts.

Results

From 3305 abstracts, 26 studies were included, ranging from 118 to 239,216 participants. Risk of CHIP was higher in those with hypertension (Odds Ratio [OR] 1.1, 95% confidence interval

SUBMITTER: Singh J 

PROVIDER: S-EPMC12573468 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature