Association of Triglyceride-Glucose Index With Different Cardiovascular Diseases in Non-Diabetic Hypertension.

ABSTRACT: This research intends to explore the association of the triglyceride-glucose (TyG) index with cardiovascular disease (CVD) death, stroke, myocardial infarction (MI), heart failure (HF) and peripheral arterial disease (PAD) in non-diabetic hypertension. This post hoc analysis uses data from a large-scale randomised controlled trial (RCT) study-Systolic Blood Pressure Intervention Trial (SPRINT), and we used Cox proportional hazards regression to explore the relationship between TyG and different CVDs. This longitudinal analysis of 9323 participants revealed a significant positive association between the TyG index and CVD death (HR 1.91, 95% CI 1.34, 2.73), HF (HR 1.43, 95% CI 1.05, 1.94), MI (HR 1.30, 95% CI 1.00, 1.69), stroke (HR 1.60, 95% CI 1.16, 2.21) and PAD (HR 1.78, 95% CI 1.30, 2.4

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC12573475 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature