Association between triglyceride-glucose index and risk of chronic kidney disease: a meta-analysis.

ABSTRACT: The triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, has been increasingly investigated for its predictive value in chronic kidney disease (CKD). However, many existing studies are cross-sectional, and the longitudinal evidence remains inconclusive. This meta-analysis aimed to evaluate the association between baseline TyG index and the incidence of CKD in adults. A systematic search of PubMed, Embase, and Web of Science was conducted through March 2025. Longitudinal cohort studies assessing the relationship between TyG index and CKD risk in adults were included. Random-effects models were used to calculate pooled risk ratios (RRs) with 95% confidence intervals (CIs). Thirteen datasets from 12 cohort studies (n = 58,838) were included. A high TyG index at

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12573563 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature