Radiotherapy combined with first-line anti-programmed cell death protein 1 (PD-1) immunotherapy and chemotherapy for patients with advanced non-small cell lung cancer: A bicentric retrospective study.

ABSTRACT:

Background

Several studies have demonstrated the synergistic effects of immunotherapy and radiotherapy for both local and abscopal tumor control. However, data regarding the use of first-line immunochemotherapy (ICT) combined with radiotherapy for advanced non-small cell lung cancer (NSCLC) remain limited. This study investigated the efficacy and safety of first-line immunochemotherapy combined with radiotherapy (ICRT) and those of ICT alone.

Methods

Patients with advanced NSCLC who received first-line anti-programmed cell death protein 1 (PD-1) immunotherapy plus chemotherapy at Wuhan Union Hospital and Hunan Cancer Hospital between October 2017 and July 2021 were retrospectively analyzed. The objective response rate (ORR), progression-free survival (PFS), overall survival

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12573630 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature