Omics-derived biological modules reflect tau positron emission tomography in Alzheimer's disease.

ABSTRACT:

Background

Tau neurofibrillary pathology is a hallmark of Alzheimer's disease (AD) and can be quantified in vivo using tau-selective positron emission tomography (tau PET). Tau PET signal closely correlates with cognitive decline and disease stage, yet the molecular networks underpinning tau accumulation remain incompletely defined.

Methods

We performed multi-omics integration of proteomics, transcriptomics, and tau PET standardized uptake value ratios (SUVRs), and clinical assessments data from cognitively normal and cognitively impaired individuals. Using Light Gradient Boosting Machine (LightGBM), two-way orthogonal partial least squares, and network-based approaches, we explored key tau-associated proteomic signatures and constructed protein-protein interaction (PPI) mod

SUBMITTER: Gu SC 

PROVIDER: S-EPMC12573779 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature