Cost-effectiveness of preventive treatment regimens for latent tuberculosis infection among key community-level populations.

ABSTRACT:

Background

Expanding tuberculosis preventive treatment (TPT) for high-risk populations with latent tuberculosis infection (LTBI) is a key component of the End TB Strategy. However, the high-risk population size is small, which may have limited impact on reducing TB incidence. We aimed to evaluate the health impact and cost-effectiveness of expanding TPT to key community-level population METHODS: We developed a dynamic transmission model incorporating the effect of TPT and seasonal variations in TB incidence. The model was calibrated by monthly pulmonary tuberculosis (PTB) case data during 2011-2018 from Shaanxi province, China, and validated by data in 2019. We first assessed the TB epidemic trend for seven expanding TPT strategies and sought the optimal TPT strategy that can reach

SUBMITTER: Jiang H 

PROVIDER: S-EPMC12573836 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature