Linarin alleviates enterotoxigenic Escherichia coli-induced small intestinal mucosal barrier damage in a piglet model by modulating the gut microbiota.

ABSTRACT:

Background

This study aimed to investigate the preventive effects of dietary linarin supplementation on Enterotoxigenic coli (ETEC) induced small intestinal barrier dysfunction in weaned piglets via gut microbiota modulation.

Results

Twenty-four weaned piglets were randomly assigned to four experimental groups. The four treatments were as follows: BD + NB (basal diet and orally administered nutrient broth), LN + NB (basal diet supplemented with 150 mg/kg linarin, and orally administered nutrient broth), BD + ETEC (basal diet and orally administered ETEC), LN + ETEC (basal diet supplemented with 150 mg/kg linarin, and orally administered ETEC). The results showed that linarin lowers the serum levels of diamine oxidase (DAO), endotoxin, and D-lactate (P < 0.05). Linarin signif

SUBMITTER: Wang M 

PROVIDER: S-EPMC12573840 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature